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Ankylosing spondylitis, an immortal cancer?


2022-01-04 15:00

Ankylosing spondylitis ( AS for short) is a type of chronic autoinflammatory disease whose cause is not fully understood. It mainly involves the central axis spine and may be accompanied by extra-articular manifestations. In severe cases, spinal deformity and joint ankylosis may occur. disease. Its incidence is related to factors such as genetics, infection, and environment. It has been found to be strongly related to HLA-B27. The prevalence of AS in the Chinese population is about 0.3%, and there are about 5 million patients with ankylosing spondylitis.

Ankylosing spondylitis is an ancient disease!


Some skeletons dating back to 4500 BC, the remains of Alexander the Great's soldiers from 330 BC, also show characteristic AS lesions. Using modern equipment, Prtrie found that two Egyptian skeletons from 1500 BC had the characteristic changes of AS radiology. The Bronze Age skeleton discovered by Parson in 1913 and the Neolithic Swede skeleton discovered by Furst in 1914 all have AS changes.


Does Ankylosing Spondylitis Affect Lifespan?

Ankylosing spondylitis generally does not affect life expectancy. Although there is currently no treatment at home and abroad that can cure ankylosing spondylitis, if you can choose a regular hospital for correct treatment to alleviate or control the disease, it will generally develop benign and will not affect the health of some important organs. Therefore, life expectancy is generally not affected.


What are the characteristics of ankylosing spondylitis?

01 There is no cure yet

So far there is no way to completely cure ankylosing spondylitis, but through some correct treatment methods, the disease can be controlled and the symptoms can be relieved. Taking non-steroidal anti-inflammatory drugs can relieve pain, improve sleep and fatigue and other uncomfortable symptoms, and taking DMARDS antirheumatic drugs or biological agents can relieve the disease or slow down the progress of the disease. With proper functional exercise, early patients can even go to school and work like normal people.

02 Early diagnosis is difficult, and the rate of misdiagnosis and missed diagnosis is
high. Ankylosing spondylitis often has an insidious onset, and the early symptoms are often atypical. There are many patients with extra-articular symptoms, such as hip joints, knee joints, ankle joints, etc., and early symptoms of pain to the hospital Seeing a doctor, the current rate of clinical missed or misdiagnosed is high, mainly because it takes 5-10 years from early symptoms to X-ray imaging changes, and in addition, the proportion of early axial joint involvement is not high. In 2009, ASAS (International Spondyloarthritis Society) released the classification criteria for axial spondyloarthritis, which included MRI examination and HLA-B27 genotyping examination in the guidelines for the first time.

03 affects everyone differently

Ankylosing spondylitis is characterized by alternating spontaneous remission and exacerbation, especially in the early stage of onset. In addition, the impact of ankylosing spondylitis on each patient is different. For patients with better prognosis, the lesions are usually mild or self-limited. Most patients can work and study normally. In contrast, some patients present with persistent disease activity, and severe disability may occur even in the early stages of the disease.


04 causes low back pain

Ankylosing spondylitis can easily lead to low back pain, especially when the disease flares up. The spine and the lumbar spine are connected together. When inflammation invades the sacroiliac joints, it will cause pain and discomfort in the lower back. In severe cases, the activities of the lower back may even be restricted, and the pain will become more obvious at night.

05 causes swelling in the spine

The main site of ankylosing spondylitis is the spine, so there will be dysfunction in the spine in the early onset, such as swelling of the spine, limitation of spinal mobility, etc. This is due to the protective spasm around the spine and the inflammation of the spine structure. caused by damage.

06Symptoms that cause sedentary difficulty

Patients with ankylosing spondylitis are prone to difficulty standing after sitting for a long time, and are often accompanied by symptoms of waist stiffness and leg numbness, which will be relieved after exercise. Therefore, it is necessary to pay attention to the symptoms of difficulty standing after sitting for a long time. It is recommended to go to the hospital for examination and corresponding treatment in time to avoid more serious consequences.



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