On March 6, 2022, sponsored by Luoyang Hospital of Traditional Chinese Medicine and co-organized by Jiangxi Karma Group, the first "Lucky Pregnancy with You" Symposium on Recurrent Miscarriage Diagnosis and Treatment was successfully held in Luoyang, Henan. With the theme of "2022 New Hotspots, New Knowledge, and New Experiences in the Diagnosis and Treatment of Recurrent Miscarriage", this academic seminar focuses on the diagnosis and treatment of recurrent miscarriage, etiological screening, immune factors, new progress in diagnosis and treatment, Sjogren's syndrome and recurrent miscarriage , HLA gene compatibility screening and other key discussions were conducted, and the subject content was full of dry goods. As the Goddess Festival is approaching, nearly 40 experts in reproductive immunity from all over Luoyang enthusiastically attended the meeting.

Recurrent miscarriage is common in clinical practice, and the diagnosis and treatment status is not optimistic

The meeting was hosted by Director Yang Yanhong of Luoyang Hospital of Traditional Chinese Medicine, Professor Xue Xiuzhen of the New District Hospital of the First Affiliated Hospital of Henan University of Science and Technology, Professor Wang Fang of Luoyang Central Hospital, Dr. Lu Zonglin of Luoyang Hospital of Traditional Chinese Medicine, Director Xing Guanlin of Luoyang Central Hospital, Director Liu Jingrui of Luoyang 5111 Hospital , Director Li Kun and others attended the meeting. Director Yang Yanhong, the chairman of the conference, delivered a wonderful meeting speech. On behalf of the Luoyang Professional Committee of Gynecology of Integrated Traditional Chinese and Western Medicine, he thanked all the participating experts for participating in the meeting, and thanked Jiangxi Karma Group for its strong support for this meeting. At present, China will have a population of 10.62 million births in 2021, with a birth rate of 7.52‰. The fertility rate has hit a new low, and population growth is facing a severe situation. In clinical work, patients with recurrent miscarriage are relatively common, and nearly 40% of them cannot find out the cause, and the patients are on the verge of collapse. Therefore, it is very meaningful to hold an academic seminar with the theme of "New Hotspots, New Knowledge, and New Experiences in Diagnosis and Treatment of Recurrent Miscarriage" today. It will be of great help to improve the diagnosis and treatment of recurrent miscarriage for clinicians, save collapsed patients, and achieve a complete family.

Patients with alloimmune abortion should be screened for HLA gene compatibility of both spouses

Director Lu Zonglin gave a keynote speech on "Immune Recurrent Miscarriage Diagnosis and Treatment Ideas". Immune recurrent miscarriage refers to spontaneous abortions related to immunity (autoimmunity and alloimmunity) and more than 2 times. According to the latest research results of Zhao Aimin from Shanghai Renji Hospital, immune factors account for about 54% of the causes of recurrent miscarriage, among which autoimmune abnormalities account for 17.8%, and alloimmune abnormalities (also known as unexplained recurrent miscarriage) account for 36.51%. At present, the possible abnormalities of alloimmunization mainly include negative blocking antibodies and high HLA compatibility between the husband and wife. Alloimmune patients need to do HLA gene compatibility testing between husband and wife, the principle is similar to HLA gene screening before kidney transplantation. At present, Luoyang Hospital of Traditional Chinese Medicine has screened dozens of IVF patients with repeated implantation failures for HLA gene compatibility between husband and wife, and found that HLA gene compatibility is more common.

Professor Xue Xiuzhen from the First Affiliated New District Hospital of Henan University of Science and Technology focused on the screening of causes of recurrent miscarriage, and made a detailed and in-depth interpretation of the "Expert Consensus on Diagnosis and Treatment of Recurrent Miscarriage in 2016". The prognosis for couples with recurrent miscarriages is generally good, but the likelihood of a successful future pregnancy depends on the age of the mother and the number of miscarriages. From an epidemiological point of view, RSA is closely related to female age, male age, body weight, living habits, and lifestyle. At present, the common known causes of RSA include prethrombotic state, genetic factors, anatomical factors, endocrine factors, immune factors, infection factors, and male factors. Finally, it is emphasized that the diagnosis and treatment of RSA patients should be multidisciplinary and individualized by obstetrics and gynecology, rheumatology, endocrinology, neurology, and psychiatry.

80%-90% of unexplained recurrent miscarriages are caused by immune factors

Director Xing Guanlin of Luoyang Central Hospital shared with you "Immune Factors in Recurrent Miscarriage". 80-90% of unexplained recurrent miscarriages are caused by immune factors, autoimmune factors (including antiphospholipid syndrome, systemic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis, systemic sclerosis, undifferentiated connective tissue disease) and pregnancy.

Director Liu Jingrui of Luoyang 5111 Hospital gave a wonderful speech on "Sjögren's syndrome and precise miscarriage", focusing on a typical case of successful miscarriage in a patient with Sjögren's syndrome.

Director Li Kun introduced the new progress of reproductive immunology diagnosis and treatment in detail, and showed some of the latest research results and diagnosis and treatment experience of well-known domestic experts, which won warm applause from the meeting. The atmosphere was very enthusiastic, which pushed the meeting to a climax.

HLA gene compatibility detection between husband and wife, interpretation of recurrent miscarriage from the genetic level

Liu Zhitao from the Marketing Department of Jiangxi Karma Group mainly introduced the company's research results in the full range of HLA gene screening. The current research results show that the vast majority of alloimmune recurrent miscarriage patients are related to the high similarity of HLA genes between husband and wife If both husband and wife share multiple HLA loci, they will not be able to stimulate the mother to produce blocking antibodies needed to maintain the pregnancy, and the mother's immune system will easily have an immunological attack on the fetus, which will reject the fetus as a foreign body and cause miscarriage. High similarity of HLA class Ⅰ molecules (HLA-A, B and C) between couples is likely to cause late miscarriage, and high similarity of HLA class Ⅱ molecules (HLA-DR, DP and DQ) between couples is likely to cause miscarriage before 6 weeks If the HLA compatibility between the husband and wife is greater than 2 sites, the research results such as active immunotherapy of lymphocytes from third-party normal individuals should be used, and finally, more authoritative large-sample clinical studies in China are expected to confirm. The first phase of the "Lucky Pregnancy with You" series of brand activities was held today, aiming to improve clinicians' awareness and diagnosis and treatment of recurrent miscarriage. The company will continue to serve doctors in the field of academic promotion.

Finally, Professor Wang Fang from Luoyang Central Hospital made wonderful comments on this meeting. Today, everyone discussed the cause of recurrent miscarriage screening, diagnosis and treatment strategies, etc. It is very meaningful to hold this meeting on this special festival. The ultimate goal of the meeting is to make the patient conceive, keep well, and give birth. I look forward to seeing you in the next meeting.